Assay Detail
Binding
CHEMBL2379237
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Displacement of [3H]-raclopride from human dopamine D2L receptor expressed in HEK293 cells after 1 hr
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.05 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2377590 | — | — | 1 | 7.85 |
| CHEMBL2377445 | — | — | 1 | 7.10 |
| CHEMBL2377591 | — | — | 1 | 6.79 |
| CHEMBL2377443 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2377590 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL2377445 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL2377591 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL2377443 | — | Ki | = | 343.0 | nM | 6.46 |