Assay Detail
Functional
CHEMBL2379295
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Antimitotic activity in human HeLa cells assessed as cell density loss after 24 hrs by Hoechst 33342 staining
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.40 | 7.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.49 |
| CHEMBL285901 | — | — | 1 | 6.45 |
| CHEMBL220818 | — | — | 1 | 6.17 |
| CHEMBL484145 | — | — | 1 | 5.48 |
| CHEMBL1946988 | — | — | 1 | - |
| CHEMBL7976 | CHALCONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | EC50 | = | 32.5 | nM | 7.49 |
| CHEMBL285901 | — | EC50 | = | 357.0 | nM | 6.45 |
| CHEMBL220818 | — | EC50 | = | 684.0 | nM | 6.17 |
| CHEMBL484145 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1946988 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL7976 | CHALCONE | EC50 | > | 50000.0 | nM | - |