Assay Detail
Functional
CHEMBL2379360
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Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic bisbenzylisoquinoline alkaloids from Stephania epigaea.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.38 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505900 | — | — | 1 | 5.64 |
| CHEMBL449782 | CEPHARANTHINE | 2.0 | 1 | 5.54 |
| CHEMBL504256 | FANGCHINOLINE | — | 1 | 5.30 |
| CHEMBL509855 | HOMOAROMOLINE | — | 1 | 5.02 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | - |
| CHEMBL2375504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505900 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL449782 | CEPHARANTHINE | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL504256 | FANGCHINOLINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL509855 | HOMOAROMOLINE | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | - | — | - | |
| CHEMBL2375504 | — | IC50 | > | 10000.0 | nM | - |