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Assay Detail

CHEMBL2379644

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Functional
Antileishmanial activity against promastigote of Leishmania donovani after 72 hrs by alamar blue assay
ChEMBL ↗
76
Total Activities
38
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367) ↗
Type ORGANISM
Organism Leishmania donovani

Publication

Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
Bharate SB, Bharate JB, Khan SI, Tekwani BL, Jacob MR, Mudududdla R, Yadav RR, Singh B, Sharma PR, Maity S, Singh B, Khan IA, Vishwakarma RA.
Eur J Med Chem (2013) 63 : 435 -443
PubMed 23517732 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC90 38 - -
IC50 38 4.67 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267345 AMPHOTERICIN B 4.0 2 6.77
CHEMBL2376544 — — 2 5.52
CHEMBL55 PENTAMIDINE 4.0 2 5.48
CHEMBL2376549 — — 2 5.35
CHEMBL2376553 — — 2 5.18
CHEMBL2376547 — — 2 5.10
CHEMBL579255 — — 2 5.08
CHEMBL2376550 — — 2 5.01
CHEMBL2376538 — — 2 4.92
CHEMBL1995195 — — 2 4.80
CHEMBL2376541 — — 2 4.80
CHEMBL2376558 — — 2 4.75
CHEMBL2376551 — — 2 4.72
CHEMBL2376552 — — 2 4.68
CHEMBL572433 — — 2 4.62
CHEMBL2376559 — — 2 4.57
CHEMBL574091 — — 2 4.57
CHEMBL2376557 — — 2 4.56
CHEMBL2376540 — — 2 4.49
CHEMBL2376537 — — 2 4.46
CHEMBL2376535 — — 2 4.43
CHEMBL2376534 — — 2 4.42
CHEMBL2376690 — — 2 4.39
CHEMBL2376536 — — 2 4.18
CHEMBL2376556 — — 2 4.09
CHEMBL2376543 — — 2 4.09
CHEMBL2376554 — — 2 4.09
CHEMBL2376691 — — 2 4.08
CHEMBL2376693 — — 2 4.07
CHEMBL1373985 — — 2 4.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267345 AMPHOTERICIN B IC50 = 170.0 nM 6.77
CHEMBL2376544 — IC50 = 3020.0 nM 5.52
CHEMBL55 PENTAMIDINE IC50 = 3290.0 nM 5.48
CHEMBL2376549 — IC50 = 4490.0 nM 5.35
CHEMBL2376553 — IC50 = 6610.0 nM 5.18
CHEMBL2376547 — IC50 = 7880.0 nM 5.10
CHEMBL579255 — IC50 = 8350.0 nM 5.08
CHEMBL2376550 — IC50 = 9840.0 nM 5.01
CHEMBL2376538 — IC50 = 12080.0 nM 4.92
CHEMBL1995195 — IC50 = 15940.0 nM 4.80
CHEMBL2376541 — IC50 = 15750.0 nM 4.80
CHEMBL2376558 — IC50 = 17630.0 nM 4.75
CHEMBL2376551 — IC50 = 19070.0 nM 4.72
CHEMBL2376552 — IC50 = 20770.0 nM 4.68
CHEMBL572433 — IC50 = 24250.0 nM 4.62
CHEMBL574091 — IC50 = 26790.0 nM 4.57
CHEMBL2376559 — IC50 = 26660.0 nM 4.57
CHEMBL2376557 — IC50 = 27450.0 nM 4.56
CHEMBL2376540 — IC50 = 32700.0 nM 4.49
CHEMBL2376537 — IC50 = 34650.0 nM 4.46
CHEMBL2376535 — IC50 = 37270.0 nM 4.43
CHEMBL2376534 — IC50 = 38070.0 nM 4.42
CHEMBL2376690 — IC50 = 41150.0 nM 4.39
CHEMBL2376536 — IC50 = 66550.0 nM 4.18
CHEMBL2376556 — IC50 = 80720.0 nM 4.09
CHEMBL2376543 — IC50 = 81060.0 nM 4.09
CHEMBL2376554 — IC50 = 82040.0 nM 4.09
CHEMBL2376691 — IC50 = 82860.0 nM 4.08
CHEMBL1373985 — IC50 = 84970.0 nM 4.07
CHEMBL2376693 — IC50 = 85950.0 nM 4.07
CHEMBL2376692 — IC50 = 89030.0 nM 4.05
CHEMBL1939127 — IC50 = 92840.0 nM 4.03
CHEMBL2376555 — IC90 - — -
CHEMBL2376548 — IC90 - — -
CHEMBL2376546 — IC90 - — -
CHEMBL2376545 — IC90 - — -
CHEMBL2376542 — IC90 - — -
CHEMBL1373985 — IC90 = 95630.0 nM -
CHEMBL2376538 — IC90 = 18810.0 nM -
CHEMBL579255 — IC90 = 19780.0 nM -
CHEMBL2376550 — IC90 = 18220.0 nM -
CHEMBL2376558 — IC90 = 22940.0 nM -
CHEMBL2376553 — IC90 = 12180.0 nM -
CHEMBL2376547 — IC90 = 10160.0 nM -
CHEMBL2376549 — IC90 = 8470.0 nM -
CHEMBL2376544 — IC90 = 6220.0 nM -
CHEMBL55 PENTAMIDINE IC90 = 6210.0 nM -
CHEMBL267345 AMPHOTERICIN B IC90 = 350.0 nM -
CHEMBL2376552 — IC90 = 37940.0 nM -
CHEMBL2376551 — IC90 = 53200.0 nM -