Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2379690

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NCI-H446 cells after 24 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H446
Confidence 1 — Organism
Curated By Autocuration

Target

NCI-H446 (CHEMBL612440)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives.
He YF, Nan ML, Sun JM, Meng ZJ, Li W, Zhang M.
Bioorg Med Chem Lett (2013) 23 : 2543 -2547
PubMed 23558236 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.79 5.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2376777 1 5.29
CHEMBL2376776 1 5.26
CHEMBL2376775 1 5.18
CHEMBL2376774 1 5.15
CHEMBL2376778 1 5.15
CHEMBL1271052 ROTUNDIC ACID 1 4.94
CHEMBL2376785 1 4.89
CHEMBL2376782 1 4.86
CHEMBL2376784 1 4.83
CHEMBL2376783 1 4.73
CHEMBL2376781 1 4.68
CHEMBL2376779 1 4.61
CHEMBL2376787 1 4.61
CHEMBL2376771 1 4.57
CHEMBL2376780 1 4.40
CHEMBL2376786 1 4.16
CHEMBL2376772 1 4.15
CHEMBL2376773 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2376777 IC50 = 5080.0 nM 5.29
CHEMBL2376776 IC50 = 5510.0 nM 5.26
CHEMBL2376775 IC50 = 6670.0 nM 5.18
CHEMBL2376774 IC50 = 7110.0 nM 5.15
CHEMBL2376778 IC50 = 7030.0 nM 5.15
CHEMBL1271052 ROTUNDIC ACID IC50 = 11400.0 nM 4.94
CHEMBL2376785 IC50 = 12820.0 nM 4.89
CHEMBL2376782 IC50 = 13960.0 nM 4.86
CHEMBL2376784 IC50 = 14690.0 nM 4.83
CHEMBL2376783 IC50 = 18620.0 nM 4.73
CHEMBL2376781 IC50 = 20890.0 nM 4.68
CHEMBL2376779 IC50 = 24720.0 nM 4.61
CHEMBL2376787 IC50 = 24830.0 nM 4.61
CHEMBL2376771 IC50 = 26920.0 nM 4.57
CHEMBL2376780 IC50 = 39810.0 nM 4.40
CHEMBL2376786 IC50 = 69690.0 nM 4.16
CHEMBL2376772 IC50 = 70790.0 nM 4.15
CHEMBL2376773 IC50 > 100000.0 nM -