Assay Detail
Functional
CHEMBL2379847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of apoptosis in human A673 cells assessed as caspase-3 activation after 24 hrs by luminescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A673 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.92 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 7.96 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.41 |
| CHEMBL2377825 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2377825 | — | EC50 | = | 410.0 | nM | 6.39 |