Assay Detail
Functional
CHEMBL2379930
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Antiproliferative activity against human MIAPaCa2 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of allosteric MEK inhibitors. Part 1: Venturing into underexplored SAR territories.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.42 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.77 |
| CHEMBL2376666 | — | — | 1 | 7.64 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2376666 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 142.0 | nM | 6.85 |