Assay Detail
Binding
CHEMBL2380058
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Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sulfurihydrogenibium yellowstonense |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 7.31 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.35 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 8.28 |
| CHEMBL13646 | — | — | 1 | 8.26 |
| CHEMBL269122 | — | — | 1 | 8.19 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 8.18 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 8.16 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 8.14 |
| CHEMBL268439 | — | — | 1 | 8.11 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 8.11 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 8.09 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 8.09 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 8.07 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.03 |
| CHEMBL13630 | — | — | 1 | 8.01 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.91 |
| CHEMBL7092 | — | — | 1 | 7.38 |
| CHEMBL268177 | — | — | 1 | 7.35 |
| CHEMBL269628 | — | — | 1 | 7.21 |
| CHEMBL14182 | — | — | 1 | 7.18 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 7.17 |
| CHEMBL6853 | — | — | 1 | 7.17 |
| CHEMBL6633 | — | — | 1 | 7.15 |
| CHEMBL287117 | — | — | 1 | 7.14 |
| CHEMBL7087 | — | — | 1 | 7.14 |
| CHEMBL6724 | — | — | 1 | 7.12 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.08 |
| CHEMBL266240 | — | — | 1 | 7.06 |
| CHEMBL265674 | — | — | 1 | 6.86 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL865 | VALDECOXIB | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL13646 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL269122 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL118 | CELECOXIB | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL268439 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL328560 | SULTHIAME | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL13630 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL7092 | — | Ki | = | 41.2 | nM | 7.38 |
| CHEMBL268177 | — | Ki | = | 44.8 | nM | 7.35 |
| CHEMBL269628 | — | Ki | = | 61.2 | nM | 7.21 |
| CHEMBL14182 | — | Ki | = | 66.4 | nM | 7.18 |
| CHEMBL26 | SULPIRIDE | Ki | = | 67.4 | nM | 7.17 |
| CHEMBL6853 | — | Ki | = | 68.3 | nM | 7.17 |
| CHEMBL6633 | — | Ki | = | 70.1 | nM | 7.15 |
| CHEMBL287117 | — | Ki | = | 72.4 | nM | 7.14 |
| CHEMBL7087 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL6724 | — | Ki | = | 75.7 | nM | 7.12 |
| CHEMBL77517 | INDISULAM | Ki | = | 84.1 | nM | 7.08 |
| CHEMBL266240 | — | Ki | = | 87.3 | nM | 7.06 |
| CHEMBL265674 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL6685 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL419 | MAFENIDE | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL6753 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL35118 | — | Ki | = | 493.0 | nM | 6.31 |
| CHEMBL6852 | — | Ki | = | 652.0 | nM | 6.19 |
| CHEMBL6919 | — | Ki | = | 695.0 | nM | 6.16 |
| CHEMBL6705 | — | Ki | = | 707.0 | nM | 6.15 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 803.0 | nM | 6.09 |
| CHEMBL7204 | — | Ki | = | 848.0 | nM | 6.07 |
| CHEMBL310671 | SACCHARIN | Ki | = | 876.0 | nM | 6.06 |