Assay Detail
Binding
CHEMBL2380059
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Inhibition of Helicobacter pylori recombinant alpha carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.48 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.68 |
| CHEMBL266240 | — | — | 1 | 7.31 |
| CHEMBL269122 | — | — | 1 | 7.08 |
| CHEMBL6633 | — | — | 1 | 6.98 |
| CHEMBL13630 | — | — | 1 | 6.94 |
| CHEMBL268439 | — | — | 1 | 6.88 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.76 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.71 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.69 |
| CHEMBL14182 | — | — | 1 | 6.68 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.68 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.65 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.64 |
| CHEMBL13646 | — | — | 1 | 6.57 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.50 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 6.50 |
| CHEMBL265674 | — | — | 1 | 6.49 |
| CHEMBL7092 | — | — | 1 | 6.42 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.42 |
| CHEMBL269628 | — | — | 1 | 6.38 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.38 |
| CHEMBL6705 | — | — | 1 | 6.37 |
| CHEMBL7204 | — | — | 1 | 6.37 |
| CHEMBL6724 | — | — | 1 | 6.34 |
| CHEMBL6852 | — | — | 1 | 6.34 |
| CHEMBL268177 | — | — | 1 | 6.29 |
| CHEMBL6919 | — | — | 1 | 6.27 |
| CHEMBL6753 | — | — | 1 | 6.26 |
| CHEMBL35118 | — | — | 1 | 6.06 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL266240 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL269122 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL6633 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL13630 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL268439 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL26 | SULPIRIDE | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL14182 | — | Ki | = | 207.0 | nM | 6.68 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 231.0 | nM | 6.64 |
| CHEMBL13646 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL265674 | — | Ki | = | 323.0 | nM | 6.49 |
| CHEMBL7092 | — | Ki | = | 378.0 | nM | 6.42 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 378.0 | nM | 6.42 |
| CHEMBL77517 | INDISULAM | Ki | = | 413.0 | nM | 6.38 |
| CHEMBL269628 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL6705 | — | Ki | = | 426.0 | nM | 6.37 |
| CHEMBL7204 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL6724 | — | Ki | = | 452.0 | nM | 6.34 |
| CHEMBL6852 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL268177 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL6919 | — | Ki | = | 541.0 | nM | 6.27 |
| CHEMBL6753 | — | Ki | = | 549.0 | nM | 6.26 |
| CHEMBL35118 | — | Ki | = | 876.0 | nM | 6.06 |
| CHEMBL419 | MAFENIDE | Ki | = | 873.0 | nM | 6.06 |
| CHEMBL287117 | — | Ki | = | 1052.0 | nM | 5.98 |
| CHEMBL6685 | — | Ki | = | 1134.0 | nM | 5.95 |
| CHEMBL7087 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL6853 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 4360.0 | nM | 5.36 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | - | — | - | |
| CHEMBL865 | VALDECOXIB | Ki | - | — | - | |
| CHEMBL118 | CELECOXIB | Ki | - | — | - | |
| CHEMBL328560 | SULTHIAME | Ki | - | — | - | |
| CHEMBL310671 | SACCHARIN | Ki | - | — | - |