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Assay Detail

CHEMBL2380080

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition interleukin-5 in mouse Y16 cells after 48 hrs by WST-1 assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type Y16
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Interleukin-5 (CHEMBL1163111)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Design and synthesis of novel chromenone derivatives as interleukin-5 inhibitors.
Venkateswararao E, Sharma VK, Lee KC, Roh E, Kim Y, Jung SH.
Bioorg Med Chem (2013) 21 : 2543 -2550
PubMed 23523388 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 4.92 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2377405 1 5.40
CHEMBL1164199 1 5.24
CHEMBL2377406 1 5.19
CHEMBL2377412 1 5.10
CHEMBL2377409 1 5.05
CHEMBL2377410 1 5.05
CHEMBL486626 SOPHORICOSIDE 1 4.97
CHEMBL2377404 1 4.92
CHEMBL2377398 1 4.85
CHEMBL2377394 1 4.82
CHEMBL2377413 1 4.82
CHEMBL2377395 1 4.80
CHEMBL2377402 1 4.77
CHEMBL2377414 1 4.77
CHEMBL2377399 1 4.70
CHEMBL2377401 1 4.66
CHEMBL1370 BUDESONIDE 4.0 1 4.57
CHEMBL2377416 1 -
CHEMBL2377393 1 -
CHEMBL2377396 1 -
CHEMBL2377397 1 -
CHEMBL2377400 1 -
CHEMBL2377403 1 -
CHEMBL2377407 1 -
CHEMBL2377408 1 -
CHEMBL2377411 1 -
CHEMBL2377415 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2377405 IC50 = 4000.0 nM 5.40
CHEMBL1164199 IC50 = 5800.0 nM 5.24
CHEMBL2377406 IC50 = 6500.0 nM 5.19
CHEMBL2377412 IC50 = 7900.0 nM 5.10
CHEMBL2377409 IC50 = 9000.0 nM 5.05
CHEMBL2377410 IC50 = 9000.0 nM 5.05
CHEMBL486626 SOPHORICOSIDE IC50 = 10600.0 nM 4.97
CHEMBL2377404 IC50 = 12000.0 nM 4.92
CHEMBL2377398 IC50 = 14000.0 nM 4.85
CHEMBL2377394 IC50 = 15000.0 nM 4.82
CHEMBL2377413 IC50 = 15000.0 nM 4.82
CHEMBL2377395 IC50 = 16000.0 nM 4.80
CHEMBL2377402 IC50 = 17000.0 nM 4.77
CHEMBL2377414 IC50 = 17000.0 nM 4.77
CHEMBL2377399 IC50 = 20000.0 nM 4.70
CHEMBL2377401 IC50 = 22000.0 nM 4.66
CHEMBL1370 BUDESONIDE IC50 = 27100.0 nM 4.57
CHEMBL2377416 IC50 > 30000.0 nM -
CHEMBL2377393 IC50 > 30000.0 nM -
CHEMBL2377396 IC50 > 30000.0 nM -
CHEMBL2377397 IC50 > 30000.0 nM -
CHEMBL2377400 IC50 > 30000.0 nM -
CHEMBL2377403 IC50 > 30000.0 nM -
CHEMBL2377407 IC50 > 30000.0 nM -
CHEMBL2377408 IC50 > 30000.0 nM -
CHEMBL2377411 IC50 > 30000.0 nM -
CHEMBL2377415 IC50 > 30000.0 nM -