Assay Detail
Functional
CHEMBL2380112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-468 cells after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.79 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2377825 | — | — | 1 | 6.52 |
| CHEMBL2377823 | — | — | 1 | 6.10 |
| CHEMBL2377864 | — | — | 1 | 5.55 |
| CHEMBL2377829 | — | — | 1 | 5.51 |
| CHEMBL2377685 | — | — | 1 | 5.26 |
| CHEMBL2377819 | — | — | 1 | - |
| CHEMBL2377818 | — | — | 1 | - |
| CHEMBL2377822 | — | — | 1 | - |
| CHEMBL2377833 | — | — | 1 | - |
| CHEMBL2377840 | — | — | 1 | - |
| CHEMBL2377839 | — | — | 1 | - |
| CHEMBL2377844 | — | — | 1 | - |
| CHEMBL2377849 | — | — | 1 | - |
| CHEMBL561114 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2377825 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2377823 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2377864 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2377829 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2377685 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2377819 | — | IC50 | - | — | - | |
| CHEMBL2377818 | — | IC50 | - | — | - | |
| CHEMBL2377822 | — | IC50 | - | — | - | |
| CHEMBL2377833 | — | IC50 | - | — | - | |
| CHEMBL2377840 | — | IC50 | - | — | - | |
| CHEMBL2377839 | — | IC50 | - | — | - | |
| CHEMBL2377844 | — | IC50 | - | — | - | |
| CHEMBL2377849 | — | IC50 | - | — | - | |
| CHEMBL561114 | — | IC50 | - | — | - |