Assay Detail
Binding
CHEMBL2380137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse brain monoamine oxidase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.66 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567517 | LACINARTIN | — | 1 | 5.04 |
| CHEMBL24171 | BERGAPTEN | 3.0 | 1 | 4.86 |
| CHEMBL2376509 | — | — | 1 | 4.56 |
| CHEMBL164660 | PSORALEN | 1.0 | 1 | 4.45 |
| CHEMBL416 | METHOXSALEN | 4.0 | 1 | 4.39 |
| CHEMBL307341 | AURAPTENE | — | 1 | - |
| CHEMBL2346911 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567517 | LACINARTIN | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL24171 | BERGAPTEN | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL2376509 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL164660 | PSORALEN | IC50 | = | 35800.0 | nM | 4.45 |
| CHEMBL416 | METHOXSALEN | IC50 | = | 40700.0 | nM | 4.39 |
| CHEMBL307341 | AURAPTENE | IC50 | = | 0.0017 | nM | - |
| CHEMBL2346911 | — | IC50 | = | 0.0007 | nM | - |