Assay Detail
Binding
CHEMBL2382452
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Inhibition of Streptococcus pneumoniae topoisomerase 4
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Streptococcus pneumoniae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.07 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2382285 | — | — | 1 | 5.43 |
| CHEMBL2159976 | — | — | 1 | 5.18 |
| CHEMBL2382286 | — | — | 1 | 5.12 |
| CHEMBL2382287 | — | — | 1 | 5.08 |
| CHEMBL2382340 | — | — | 1 | 4.52 |
| CHEMBL2158050 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2382285 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL2159976 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL2382286 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL2382287 | — | IC50 | = | 8370.0 | nM | 5.08 |
| CHEMBL2382340 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2158050 | — | IC50 | - | — | - |