Assay Detail
Functional
CHEMBL2382644
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stimulated cAMP production after 20 mins by FLIPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AV12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.92 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381641 | — | — | 1 | 6.57 |
| CHEMBL2381640 | — | — | 1 | 5.86 |
| CHEMBL2381645 | — | — | 1 | 5.72 |
| CHEMBL2381643 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381641 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL2381640 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL2381645 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL2381643 | — | IC50 | = | 3040.0 | nM | 5.52 |