Assay Detail
Binding
CHEMBL2382826
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Inhibition of hyaluronan-induced CD44 antigen variant exon 6 activity in human HCA-7 cells expressing Has2 assessed as decrease in cell survival after 18 hrs by MTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HCA-7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.55 | 4.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.76 |
| CHEMBL2380929 | — | — | 1 | 4.58 |
| CHEMBL2380930 | — | — | 1 | 4.46 |
| CHEMBL527577 | — | — | 1 | 4.41 |
| CHEMBL2380931 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL2380929 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL2380930 | — | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL527577 | — | IC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL2380931 | — | IC50 | = | 186000.0 | nM | - |