Assay Detail
Binding
CHEMBL2382935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant caspase-7 assessed as Ac-DEVD-AMC conversion to 7-amino-4-methylcoumarin incubated for 10 mins prior to substrate addition measured after 10 mins by spectrophotometric analysis
9
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.15 | 9.02 |
| Ki | 2 | 7.05 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381343 | — | — | 1 | 9.02 |
| CHEMBL2381345 | — | — | 1 | 7.57 |
| CHEMBL293034 | — | — | 1 | 7.33 |
| CHEMBL2381346 | — | — | 1 | 7.15 |
| CHEMBL2381344 | — | — | 1 | 6.99 |
| CHEMBL2381349 | — | — | 1 | 6.89 |
| CHEMBL60190 | — | — | 2 | 6.77 |
| CHEMBL2381348 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381343 | — | IC50 | = | 0.951 | nM | 9.02 |
| CHEMBL2381345 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL293034 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL2381346 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2381344 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL2381349 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL60190 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL2381348 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL60190 | — | IC50 | = | 1290.0 | nM | 5.89 |