Assay Detail
Functional
CHEMBL2383047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel orally bioavailable GPR40 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 41 | 7.20 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381289 | — | — | 1 | 7.95 |
| CHEMBL2381282 | — | — | 1 | 7.87 |
| CHEMBL2381287 | — | — | 1 | 7.80 |
| CHEMBL2381308 | — | — | 1 | 7.72 |
| CHEMBL2381306 | — | — | 1 | 7.52 |
| CHEMBL2381290 | — | — | 1 | 7.52 |
| CHEMBL2381285 | — | — | 1 | 7.47 |
| CHEMBL2381312 | — | — | 1 | 7.45 |
| CHEMBL2381291 | — | — | 1 | 7.44 |
| CHEMBL2381307 | — | — | 1 | 7.41 |
| CHEMBL2381313 | — | — | 1 | 7.41 |
| CHEMBL2047159 | — | — | 1 | 7.38 |
| CHEMBL2381295 | — | — | 1 | 7.33 |
| CHEMBL2381305 | — | — | 1 | 7.28 |
| CHEMBL2381281 | — | — | 1 | 7.26 |
| CHEMBL2381293 | — | — | 1 | 7.25 |
| CHEMBL2381310 | — | — | 1 | 7.25 |
| CHEMBL2381302 | — | — | 1 | 7.25 |
| CHEMBL2381314 | — | — | 1 | 7.21 |
| CHEMBL2380322 | — | — | 1 | 7.20 |
| CHEMBL2381311 | — | — | 1 | 7.18 |
| CHEMBL2381309 | — | — | 1 | 7.18 |
| CHEMBL2381296 | — | — | 1 | 7.17 |
| CHEMBL2381280 | — | — | 1 | 7.13 |
| CHEMBL2381318 | — | — | 1 | 7.13 |
| CHEMBL2381317 | — | — | 1 | 7.13 |
| CHEMBL2381297 | — | — | 1 | 7.08 |
| CHEMBL2381315 | — | — | 1 | 7.06 |
| CHEMBL2381299 | — | — | 1 | 7.02 |
| CHEMBL2381292 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381289 | — | EC50 | = | 11.3 | nM | 7.95 |
| CHEMBL2381282 | — | EC50 | = | 13.5 | nM | 7.87 |
| CHEMBL2381287 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2381308 | — | EC50 | = | 19.1 | nM | 7.72 |
| CHEMBL2381306 | — | EC50 | = | 30.1 | nM | 7.52 |
| CHEMBL2381290 | — | EC50 | = | 30.4 | nM | 7.52 |
| CHEMBL2381285 | — | EC50 | = | 34.2 | nM | 7.47 |
| CHEMBL2381312 | — | EC50 | = | 35.9 | nM | 7.45 |
| CHEMBL2381291 | — | EC50 | = | 36.4 | nM | 7.44 |
| CHEMBL2381307 | — | EC50 | = | 39.3 | nM | 7.41 |
| CHEMBL2381313 | — | EC50 | = | 38.7 | nM | 7.41 |
| CHEMBL2047159 | — | EC50 | = | 41.8 | nM | 7.38 |
| CHEMBL2381295 | — | EC50 | = | 46.5 | nM | 7.33 |
| CHEMBL2381305 | — | EC50 | = | 52.9 | nM | 7.28 |
| CHEMBL2381281 | — | EC50 | = | 54.7 | nM | 7.26 |
| CHEMBL2381293 | — | EC50 | = | 55.9 | nM | 7.25 |
| CHEMBL2381302 | — | EC50 | = | 56.2 | nM | 7.25 |
| CHEMBL2381310 | — | EC50 | = | 56.7 | nM | 7.25 |
| CHEMBL2381314 | — | EC50 | = | 61.6 | nM | 7.21 |
| CHEMBL2380322 | — | EC50 | = | 63.7 | nM | 7.20 |
| CHEMBL2381311 | — | EC50 | = | 65.4 | nM | 7.18 |
| CHEMBL2381309 | — | EC50 | = | 66.7 | nM | 7.18 |
| CHEMBL2381296 | — | EC50 | = | 67.5 | nM | 7.17 |
| CHEMBL2381280 | — | EC50 | = | 74.5 | nM | 7.13 |
| CHEMBL2381318 | — | EC50 | = | 73.2 | nM | 7.13 |
| CHEMBL2381317 | — | EC50 | = | 74.7 | nM | 7.13 |
| CHEMBL2381297 | — | EC50 | = | 82.4 | nM | 7.08 |
| CHEMBL2381315 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL2381299 | — | EC50 | = | 94.8 | nM | 7.02 |
| CHEMBL2381292 | — | EC50 | = | 105.1 | nM | 6.98 |
| CHEMBL2381283 | — | EC50 | = | 111.1 | nM | 6.95 |
| CHEMBL2381298 | — | EC50 | = | 120.7 | nM | 6.92 |
| CHEMBL2381301 | — | EC50 | = | 122.6 | nM | 6.91 |
| CHEMBL2381304 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL2381316 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL2381300 | — | EC50 | = | 145.2 | nM | 6.84 |
| CHEMBL2381288 | — | EC50 | = | 190.5 | nM | 6.72 |
| CHEMBL2381303 | — | EC50 | = | 205.1 | nM | 6.69 |
| CHEMBL2381286 | — | EC50 | = | 219.8 | nM | 6.66 |
| CHEMBL2381294 | — | EC50 | = | 282.0 | nM | 6.55 |
| CHEMBL2381284 | — | EC50 | > | 10000.0 | nM | - |