Assay Detail
Binding
CHEMBL2383459
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Inhibition of wild type Escherichia coli RNA polymerase after 10 mins by rolling circle transcription assay in presence of DNA nanocircle template NC45
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
X-ray crystal structures of the Escherichia coli RNA polymerase in complex with benzoxazinorifamycins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.62 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | 7.92 |
| CHEMBL2046887 | — | — | 1 | 7.68 |
| CHEMBL2046886 | — | — | 1 | 7.62 |
| CHEMBL2046885 | — | — | 1 | 7.24 |
| CHEMBL236297 | RIFALAZIL | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2046887 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2046886 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2046885 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL236297 | RIFALAZIL | IC50 | < | 10.0 | nM | - |