Assay Detail
Binding
CHEMBL2383582
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Inhibition of potato 5-LOX using arachidonic acid as substrate assessed as production of hydroperoxides after 5 mins by enzyme immunoassay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Solanum tuberosum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.31 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275835 | DARBUFELONE | 2.0 | 1 | 6.11 |
| CHEMBL2380929 | — | — | 1 | 5.29 |
| CHEMBL2380930 | — | — | 1 | 5.13 |
| CHEMBL527577 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275835 | DARBUFELONE | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL2380929 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2380930 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL527577 | — | IC50 | = | 20000.0 | nM | 4.70 |