Assay Detail
Binding
CHEMBL2383585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of sheep placental COX-2 using arachidonic acid as substrate assessed as production of PGF2alpha by enzyme immunoassay in presence of stannous chloride
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.37 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275835 | DARBUFELONE | 2.0 | 1 | 6.32 |
| CHEMBL527577 | — | — | 1 | 5.12 |
| CHEMBL2380930 | — | — | 1 | 5.03 |
| CHEMBL2380929 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275835 | DARBUFELONE | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL527577 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2380930 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL2380929 | — | IC50 | = | 9500.0 | nM | 5.02 |