Assay Detail
Binding
CHEMBL2383620
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at (alpha4beta2)2beta2 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced current after 2 mins by two-electrode voltage clamp assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907589) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Neonicotinic analogues: selective antagonists for α4β2 nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.48 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293950 | — | — | 1 | 6.39 |
| CHEMBL2381568 | — | — | 1 | 5.60 |
| CHEMBL2381563 | — | — | 1 | 5.44 |
| CHEMBL2381570 | — | — | 1 | 5.37 |
| CHEMBL2381566 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293950 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2381568 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2381563 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2381570 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2381566 | — | IC50 | = | 25800.0 | nM | 4.59 |