Assay Detail
Binding
CHEMBL2384053
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Inhibition of recombinant human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.25 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2380750 | — | — | 1 | 8.27 |
| CHEMBL2380753 | — | — | 1 | 8.19 |
| CHEMBL404954 | — | — | 1 | 8.18 |
| CHEMBL2380746 | — | — | 1 | 8.09 |
| CHEMBL2380747 | — | — | 1 | 8.02 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL2380751 | — | — | 1 | 7.88 |
| CHEMBL2380752 | — | — | 1 | 7.67 |
| CHEMBL2380749 | — | — | 1 | 7.35 |
| CHEMBL2380748 | — | — | 1 | 7.23 |
| CHEMBL2380745 | — | — | 1 | 7.22 |
| CHEMBL2380755 | — | — | 1 | 7.13 |
| CHEMBL2380754 | — | — | 1 | 7.12 |
| CHEMBL2380744 | — | — | 1 | 6.53 |
| CHEMBL2380740 | — | — | 1 | 6.53 |
| CHEMBL2380738 | — | — | 1 | 6.52 |
| CHEMBL2380739 | — | — | 1 | 6.51 |
| CHEMBL2380742 | — | — | 1 | 6.47 |
| CHEMBL2380737 | — | — | 1 | 6.46 |
| CHEMBL2380743 | — | — | 1 | 6.44 |
| CHEMBL2380741 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2380750 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL2380753 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL404954 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL2380746 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL2380747 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2380751 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL2380752 | — | Ki | = | 21.5 | nM | 7.67 |
| CHEMBL2380749 | — | Ki | = | 45.1 | nM | 7.35 |
| CHEMBL2380748 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL2380745 | — | Ki | = | 60.4 | nM | 7.22 |
| CHEMBL2380755 | — | Ki | = | 73.6 | nM | 7.13 |
| CHEMBL2380754 | — | Ki | = | 75.7 | nM | 7.12 |
| CHEMBL2380744 | — | Ki | = | 293.0 | nM | 6.53 |
| CHEMBL2380740 | — | Ki | = | 298.0 | nM | 6.53 |
| CHEMBL2380738 | — | Ki | = | 305.0 | nM | 6.52 |
| CHEMBL2380739 | — | Ki | = | 307.0 | nM | 6.51 |
| CHEMBL2380742 | — | Ki | = | 337.0 | nM | 6.47 |
| CHEMBL2380737 | — | Ki | = | 346.0 | nM | 6.46 |
| CHEMBL2380743 | — | Ki | = | 366.0 | nM | 6.44 |
| CHEMBL2380741 | — | Ki | = | 361.0 | nM | 6.44 |