Assay Detail
Functional
CHEMBL2384077
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Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiproliferative evaluation of piperazine-1-carbothiohydrazide derivatives of indolin-2-one.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.95 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.61 |
| CHEMBL2381873 | — | — | 1 | 5.45 |
| CHEMBL2381881 | — | — | 1 | 5.25 |
| CHEMBL2381886 | — | — | 1 | 5.21 |
| CHEMBL2381872 | — | — | 1 | 5.19 |
| CHEMBL2380328 | — | — | 1 | 5.13 |
| CHEMBL2381884 | — | — | 1 | 5.12 |
| CHEMBL2381870 | — | — | 1 | 5.12 |
| CHEMBL2381876 | — | — | 1 | 5.10 |
| CHEMBL2381875 | — | — | 1 | 5.10 |
| CHEMBL2381874 | — | — | 1 | 5.09 |
| CHEMBL2381877 | — | — | 1 | 5.05 |
| CHEMBL2381883 | — | — | 1 | 5.00 |
| CHEMBL2381871 | — | — | 1 | 4.99 |
| CHEMBL2381878 | — | — | 1 | 4.98 |
| CHEMBL2381879 | — | — | 1 | 4.94 |
| CHEMBL2381880 | — | — | 1 | 4.93 |
| CHEMBL2381885 | — | — | 1 | 4.91 |
| CHEMBL2381868 | — | — | 1 | 4.80 |
| CHEMBL2381865 | — | — | 1 | 4.75 |
| CHEMBL2381882 | — | — | 1 | 4.73 |
| CHEMBL2381776 | — | — | 1 | 4.68 |
| CHEMBL2381869 | — | — | 1 | 4.56 |
| CHEMBL1762456 | — | — | 1 | 4.48 |
| CHEMBL2381866 | — | — | 1 | 4.27 |
| CHEMBL2381867 | — | — | 1 | 4.25 |
| CHEMBL1528228 | — | — | 1 | - |
| CHEMBL2381775 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL2381873 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL2381881 | — | IC50 | = | 5580.0 | nM | 5.25 |
| CHEMBL2381886 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL2381872 | — | IC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL2380328 | — | IC50 | = | 7340.0 | nM | 5.13 |
| CHEMBL2381884 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL2381870 | — | IC50 | = | 7680.0 | nM | 5.12 |
| CHEMBL2381876 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL2381875 | — | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL2381874 | — | IC50 | = | 8180.0 | nM | 5.09 |
| CHEMBL2381877 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL2381883 | — | IC50 | = | 9880.0 | nM | 5.00 |
| CHEMBL2381871 | — | IC50 | = | 10130.0 | nM | 4.99 |
| CHEMBL2381878 | — | IC50 | = | 10510.0 | nM | 4.98 |
| CHEMBL2381879 | — | IC50 | = | 11380.0 | nM | 4.94 |
| CHEMBL2381880 | — | IC50 | = | 11770.0 | nM | 4.93 |
| CHEMBL2381885 | — | IC50 | = | 12250.0 | nM | 4.91 |
| CHEMBL2381868 | — | IC50 | = | 15840.0 | nM | 4.80 |
| CHEMBL2381865 | — | IC50 | = | 17910.0 | nM | 4.75 |
| CHEMBL2381882 | — | IC50 | = | 18560.0 | nM | 4.73 |
| CHEMBL2381776 | — | IC50 | = | 20730.0 | nM | 4.68 |
| CHEMBL2381869 | — | IC50 | = | 27650.0 | nM | 4.56 |
| CHEMBL1762456 | — | IC50 | = | 33140.0 | nM | 4.48 |
| CHEMBL2381866 | — | IC50 | = | 53970.0 | nM | 4.27 |
| CHEMBL2381867 | — | IC50 | = | 55930.0 | nM | 4.25 |
| CHEMBL1528228 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2381775 | — | IC50 | > | 100000.0 | nM | - |