Assay Detail
Binding
CHEMBL2384159
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Inhibition of Mycobacterium avium DHFR
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium avium |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.09 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 9.66 |
| CHEMBL2382330 | — | — | 1 | 9.24 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 9.21 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.82 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 8.82 |
| CHEMBL2382334 | — | — | 1 | 8.70 |
| CHEMBL2382327 | — | — | 1 | 8.68 |
| CHEMBL2382329 | — | — | 1 | 8.66 |
| CHEMBL2382328 | — | — | 1 | 8.17 |
| CHEMBL2382335 | — | — | 1 | 7.77 |
| CHEMBL2382332 | — | — | 1 | 7.58 |
| CHEMBL2382331 | — | — | 1 | 7.57 |
| CHEMBL2382326 | — | — | 1 | 7.57 |
| CHEMBL2382336 | — | — | 1 | 7.54 |
| CHEMBL2382333 | — | — | 1 | 6.82 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 6.82 |
| CHEMBL2382323 | — | — | 1 | 6.00 |
| CHEMBL2382314 | — | — | 1 | 5.92 |
| CHEMBL2382318 | — | — | 1 | 5.82 |
| CHEMBL2382317 | — | — | 1 | 5.77 |
| CHEMBL2382321 | — | — | 1 | 5.75 |
| CHEMBL2382316 | — | — | 1 | 5.62 |
| CHEMBL2382315 | — | — | 1 | 5.60 |
| CHEMBL2382324 | — | — | 1 | 5.48 |
| CHEMBL2382325 | — | — | 1 | 5.44 |
| CHEMBL2382319 | — | — | 1 | 5.36 |
| CHEMBL2382322 | — | — | 1 | 5.10 |
| CHEMBL2382320 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL2382330 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2382334 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2382327 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2382329 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2382328 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL2382335 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2382332 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2382331 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2382326 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2382336 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2382333 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2382323 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2382314 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2382318 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2382317 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2382321 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2382316 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2382315 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2382324 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2382325 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2382319 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2382322 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2382320 | — | IC50 | = | 8700.0 | nM | 5.06 |