Assay Detail
Binding
CHEMBL2384180
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Binding affinity to human recombinant carboxy-terminal avi-tagged LDHA (1 to 331) expressed in Escherichia coli by surface plasmon resonance analysis presence of NADH
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 21 | 5.19 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2382401 | — | — | 1 | 5.66 |
| CHEMBL2382403 | — | — | 1 | 5.54 |
| CHEMBL2382404 | — | — | 1 | 5.52 |
| CHEMBL2382402 | — | — | 1 | 5.29 |
| CHEMBL2382337 | — | — | 1 | 5.21 |
| CHEMBL2382405 | — | — | 1 | 5.05 |
| CHEMBL2382400 | — | — | 1 | 4.81 |
| CHEMBL210497 | — | — | 1 | 4.42 |
| CHEMBL2382338 | — | — | 1 | - |
| CHEMBL2382339 | — | — | 1 | - |
| CHEMBL2382389 | — | — | 1 | - |
| CHEMBL2382390 | — | — | 1 | - |
| CHEMBL2382391 | — | — | 1 | - |
| CHEMBL2382392 | — | — | 1 | - |
| CHEMBL2382393 | — | — | 1 | - |
| CHEMBL2382394 | — | — | 1 | - |
| CHEMBL2382395 | — | — | 1 | - |
| CHEMBL2382396 | — | — | 1 | - |
| CHEMBL2382397 | — | — | 1 | - |
| CHEMBL2382398 | — | — | 1 | - |
| CHEMBL2382399 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2382401 | — | Kd | = | 2200.0 | nM | 5.66 |
| CHEMBL2382403 | — | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL2382404 | — | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL2382402 | — | Kd | = | 5100.0 | nM | 5.29 |
| CHEMBL2382337 | — | Kd | = | 6100.0 | nM | 5.21 |
| CHEMBL2382405 | — | Kd | = | 8900.0 | nM | 5.05 |
| CHEMBL2382400 | — | Kd | = | 15400.0 | nM | 4.81 |
| CHEMBL210497 | — | Kd | = | 38400.0 | nM | 4.42 |
| CHEMBL2382338 | — | Kd | = | 532000.0 | nM | - |
| CHEMBL2382339 | — | Kd | = | 570000.0 | nM | - |
| CHEMBL2382389 | — | Kd | = | 552000.0 | nM | - |
| CHEMBL2382390 | — | Kd | = | 1011000.0 | nM | - |
| CHEMBL2382391 | — | Kd | = | 1105000.0 | nM | - |
| CHEMBL2382392 | — | Kd | = | 1215000.0 | nM | - |
| CHEMBL2382393 | — | Kd | = | 386000.0 | nM | - |
| CHEMBL2382394 | — | Kd | = | 462000.0 | nM | - |
| CHEMBL2382395 | — | Kd | = | 1055000.0 | nM | - |
| CHEMBL2382396 | — | Kd | = | 314000.0 | nM | - |
| CHEMBL2382397 | — | Kd | = | 466000.0 | nM | - |
| CHEMBL2382398 | — | Kd | = | 640000.0 | nM | - |
| CHEMBL2382399 | — | Kd | = | 552000.0 | nM | - |