Assay Detail
Binding
CHEMBL2384199
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Positive allosteric modulation of rat muscarinic M5 receptor assessed as effect on acetylcholine-induced response
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M5 (CHEMBL277) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of ML326: The first sub-micromolar, selective M5 PAM.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.62 | 9.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381694 | — | — | 2 | 9.65 |
| CHEMBL466253 | — | — | 2 | 9.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381694 | — | EC50 | = | 0.2239 | nM | 9.65 |
| CHEMBL2381694 | — | EC50 | = | 0.2254 | nM | 9.65 |
| CHEMBL466253 | — | EC50 | = | 0.263 | nM | 9.58 |
| CHEMBL466253 | — | EC50 | = | 0.2634 | nM | 9.58 |