Assay Detail
Functional
CHEMBL2384296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HBV infected in human HepG2.2.15 assessed as reduction of viral e-antigen production after 24 hrs by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of new 2'-deoxy-2'-fluoro-4'-triazole cytidine nucleosides as potent antiviral agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.30 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2380664 | — | — | 1 | 6.60 |
| CHEMBL2380662 | — | — | 1 | 6.00 |
| CHEMBL2380665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2380664 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2380662 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2380665 | — | EC50 | > | 1000.0 | nM | - |