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Assay Detail

CHEMBL2384613

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Functional
Antiproliferative activity against human MIAPaCa2 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MIA PaCa-2
Confidence 1 — Organism
Curated By Autocuration

Target

MIA PaCa-2 (CHEMBL614725)
Type CELL-LINE
Organism Homo sapiens

Publication

SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.
Karra S, Xiao Y, Chen X, Liu-Bujalski L, Huck B, Sutton A, Goutopoulos A, Askew B, Josephson K, Jiang X, Shutes A, Shankar V, Noonan T, Garcia-Berrios G, Dong R, Dhanabal M, Tian H, Wang Z, Clark A, Goodstal S.
Bioorg Med Chem Lett (2013) 23 : 3081 -3087
PubMed 23570792 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.14 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2380834 1 6.77
CHEMBL2380837 1 6.68
CHEMBL2380829 1 6.68
CHEMBL2380835 1 6.60
CHEMBL2380831 1 6.53
CHEMBL2380845 1 6.48
CHEMBL2380830 1 6.43
CHEMBL2380832 1 6.39
CHEMBL2380824 1 6.39
CHEMBL2380827 1 6.14
CHEMBL2380833 1 6.08
CHEMBL2380825 1 6.04
CHEMBL2380838 1 5.92
CHEMBL2380839 1 5.65
CHEMBL2380826 1 5.62
CHEMBL2380828 1 5.57
CHEMBL2380836 1 5.30
CHEMBL2380823 1 5.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2380834 IC50 = 170.0 nM 6.77
CHEMBL2380837 IC50 = 211.0 nM 6.68
CHEMBL2380829 IC50 = 209.0 nM 6.68
CHEMBL2380835 IC50 = 253.0 nM 6.60
CHEMBL2380831 IC50 = 293.0 nM 6.53
CHEMBL2380845 IC50 = 329.0 nM 6.48
CHEMBL2380830 IC50 = 374.0 nM 6.43
CHEMBL2380832 IC50 = 409.0 nM 6.39
CHEMBL2380824 IC50 = 405.0 nM 6.39
CHEMBL2380827 IC50 = 719.0 nM 6.14
CHEMBL2380833 IC50 = 823.0 nM 6.08
CHEMBL2380825 IC50 = 919.0 nM 6.04
CHEMBL2380838 IC50 = 1190.0 nM 5.92
CHEMBL2380839 IC50 = 2220.0 nM 5.65
CHEMBL2380826 IC50 = 2390.0 nM 5.62
CHEMBL2380828 IC50 = 2710.0 nM 5.57
CHEMBL2380836 IC50 = 4990.0 nM 5.30
CHEMBL2380823 IC50 = 6250.0 nM 5.20