Assay Detail
Binding
CHEMBL2384630
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Inhibition of cathepsin B (unknown origin) using RR-AMC as substrate after 30 mins by fluorescence assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.77 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368566 | — | — | 1 | 7.18 |
| CHEMBL2382116 | — | — | 1 | 5.74 |
| CHEMBL2382117 | — | — | 1 | 4.54 |
| CHEMBL2382119 | — | — | 1 | 4.54 |
| CHEMBL2382113 | — | — | 1 | 4.33 |
| CHEMBL2382118 | — | — | 1 | 4.26 |
| CHEMBL141530 | ECHINATIN | — | 1 | 4.24 |
| CHEMBL2382114 | — | — | 1 | 4.12 |
| CHEMBL2382112 | — | — | 1 | 4.02 |
| CHEMBL2382054 | — | — | 1 | - |
| CHEMBL2382055 | — | — | 1 | - |
| CHEMBL2382056 | — | — | 1 | - |
| CHEMBL2382057 | — | — | 1 | - |
| CHEMBL2382058 | — | — | 1 | - |
| CHEMBL2382059 | — | — | 1 | - |
| CHEMBL2382115 | — | — | 1 | - |
| CHEMBL8102 | — | — | 1 | - |
| CHEMBL1928752 | — | — | 1 | - |
| CHEMBL2148111 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368566 | — | IC50 | = | 65.6 | nM | 7.18 |
| CHEMBL2382116 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL2382117 | — | IC50 | = | 28670.0 | nM | 4.54 |
| CHEMBL2382119 | — | IC50 | = | 28950.0 | nM | 4.54 |
| CHEMBL2382113 | — | IC50 | = | 46810.0 | nM | 4.33 |
| CHEMBL2382118 | — | IC50 | = | 54290.0 | nM | 4.26 |
| CHEMBL141530 | ECHINATIN | IC50 | = | 57680.0 | nM | 4.24 |
| CHEMBL2382114 | — | IC50 | = | 76470.0 | nM | 4.12 |
| CHEMBL2382112 | — | IC50 | = | 95090.0 | nM | 4.02 |
| CHEMBL2382054 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382055 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382056 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382057 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382058 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382059 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382115 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8102 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1928752 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2148111 | — | IC50 | > | 100000.0 | nM | - |