Assay Detail
Functional
CHEMBL2388009
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Neuroprotective activity in rat primary cortical neurons assessed as reduction in trophic factor withdrawal after 2 days by fluorescent live-dead assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Cerebral cortex neuron |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Metabolism of a potent neuroprotective hydrazide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.35 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2387145 | — | — | 1 | 7.92 |
| CHEMBL2387146 | — | — | 1 | 7.51 |
| CHEMBL2387144 | J147 | 1.0 | 1 | 7.48 |
| CHEMBL2387147 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2387145 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2387146 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2387144 | J147 | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2387147 | — | EC50 | = | 320.0 | nM | 6.50 |