Assay Detail
Binding
CHEMBL2388440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant placental aromatase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.44 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386285 | — | — | 1 | 7.05 |
| CHEMBL3350384 | — | — | 1 | 7.05 |
| CHEMBL1093458 | ENDOXIFEN | 3.0 | 1 | 5.22 |
| CHEMBL2137046 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386285 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3350384 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1093458 | ENDOXIFEN | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2137046 | — | IC50 | = | 530000.0 | nM | - |