Assay Detail
Binding
CHEMBL2388544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MMP7 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.17 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83508 | — | — | 1 | 5.40 |
| CHEMBL2385479 | — | — | 1 | 5.40 |
| CHEMBL550148 | — | — | 1 | 5.30 |
| CHEMBL2385489 | — | — | 1 | 5.22 |
| CHEMBL2385481 | — | — | 1 | 5.16 |
| CHEMBL2385480 | — | — | 1 | 4.97 |
| CHEMBL2385488 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83508 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL2385479 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL550148 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL2385489 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL2385481 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL2385480 | — | Ki | = | 10700.0 | nM | 4.97 |
| CHEMBL2385488 | — | Ki | = | 18500.0 | nM | 4.73 |