Assay Detail
Binding
CHEMBL2388548
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Inhibition of MMP8 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.53 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385487 | — | — | 1 | 8.52 |
| CHEMBL2385483 | — | — | 1 | 8.40 |
| CHEMBL2385492 | — | — | 1 | 8.22 |
| CHEMBL2385486 | — | — | 1 | 8.15 |
| CHEMBL550148 | — | — | 1 | 8.05 |
| CHEMBL2385489 | — | — | 1 | 7.89 |
| CHEMBL2385482 | — | — | 1 | 7.85 |
| CHEMBL2385488 | — | — | 1 | 7.70 |
| CHEMBL2385484 | — | — | 1 | 7.50 |
| CHEMBL2385490 | — | — | 1 | 7.43 |
| CHEMBL2385481 | — | — | 1 | 7.37 |
| CHEMBL83508 | — | — | 1 | 7.23 |
| CHEMBL2385480 | — | — | 1 | 7.12 |
| CHEMBL2385485 | — | — | 1 | 7.01 |
| CHEMBL2385479 | — | — | 1 | 6.62 |
| CHEMBL2385493 | — | — | 1 | 6.56 |
| CHEMBL2385491 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385487 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2385483 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2385492 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2385486 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL550148 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL2385489 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2385482 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL2385488 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2385484 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL2385490 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL2385481 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL83508 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL2385480 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL2385485 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL2385479 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL2385493 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL2385491 | — | Ki | = | 364.0 | nM | 6.44 |