Assay Detail
Functional
CHEMBL2388705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against VSV infected in MDCK cells assessed as inhibition of VSV replication after 48 hrs by plaque assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vesicular stomatitis virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Vesicular stomatitis virus (CHEMBL613739) ↗| Type | ORGANISM |
| Organism | Vesicular stomatitis virus |
Publication
SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 46 | 5.73 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385512 | — | — | 1 | 8.72 |
| CHEMBL2385511 | — | — | 1 | 7.64 |
| CHEMBL2385510 | — | — | 1 | 7.19 |
| CHEMBL2385515 | — | — | 1 | 7.00 |
| CHEMBL2385712 | — | — | 1 | 7.00 |
| CHEMBL2385507 | — | — | 1 | 6.63 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 6.52 |
| CHEMBL2385711 | — | — | 1 | 6.52 |
| CHEMBL2385719 | — | — | 1 | 6.32 |
| CHEMBL2385508 | — | — | 1 | 6.28 |
| CHEMBL2385509 | — | — | 1 | 6.25 |
| CHEMBL2385703 | — | — | 1 | 6.22 |
| CHEMBL2385710 | — | — | 1 | 6.05 |
| CHEMBL2385698 | — | — | 1 | 6.00 |
| CHEMBL2385707 | — | — | 1 | 6.00 |
| CHEMBL2385713 | — | — | 1 | 6.00 |
| CHEMBL2385699 | — | — | 1 | 5.92 |
| CHEMBL2385514 | — | — | 1 | 5.89 |
| CHEMBL2385701 | — | — | 1 | 5.80 |
| CHEMBL2385720 | — | — | 1 | 5.75 |
| CHEMBL2385708 | — | — | 1 | 5.70 |
| CHEMBL2385696 | — | — | 1 | 5.70 |
| CHEMBL2385705 | — | — | 1 | 5.68 |
| CHEMBL153238 | — | — | 1 | 5.66 |
| CHEMBL2385504 | — | — | 1 | 5.60 |
| CHEMBL2385516 | — | — | 1 | 5.51 |
| CHEMBL2385715 | — | — | 1 | 5.33 |
| CHEMBL2385709 | — | — | 1 | 5.31 |
| CHEMBL2385717 | — | — | 1 | 5.24 |
| CHEMBL2385722 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385512 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2385511 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2385510 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2385515 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2385712 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2385507 | — | EC50 | = | 235.0 | nM | 6.63 |
| CHEMBL38434 | BREQUINAR | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2385711 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2385719 | — | EC50 | = | 479.0 | nM | 6.32 |
| CHEMBL2385508 | — | EC50 | = | 522.0 | nM | 6.28 |
| CHEMBL2385509 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2385703 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2385710 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2385713 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2385698 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2385707 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2385699 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2385514 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2385701 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2385720 | — | EC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL2385708 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2385696 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2385705 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL153238 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2385504 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2385516 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2385715 | — | EC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL2385709 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL2385717 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL2385722 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL2385718 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL2385702 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2385706 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2385716 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL38614 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2385721 | — | EC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL2385506 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2385505 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL2385697 | — | EC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL2385704 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2385714 | — | EC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL2385513 | — | EC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL2385503 | — | EC50 | = | 86460.0 | nM | 4.06 |
| CHEMBL2385694 | — | EC50 | = | 95600.0 | nM | 4.02 |
| CHEMBL2385695 | — | EC50 | = | 2611000.0 | nM | - |
| CHEMBL2385700 | — | EC50 | = | 158800.0 | nM | - |