Assay Detail
Binding
CHEMBL2388914
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Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Dihydrooxazines As Inhibitors of BACE-1 or BACE-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.68 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386721 | — | — | 1 | 8.15 |
| CHEMBL2386719 | — | — | 1 | 8.15 |
| CHEMBL2386720 | — | — | 1 | 8.10 |
| CHEMBL2386724 | — | — | 1 | 7.92 |
| CHEMBL2386726 | — | — | 1 | 7.89 |
| CHEMBL2386723 | — | — | 1 | 7.57 |
| CHEMBL2386722 | — | — | 1 | 7.31 |
| CHEMBL2386725 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386721 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2386719 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2386720 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2386724 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2386726 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2386723 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2386722 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2386725 | — | IC50 | = | 440.0 | nM | 6.36 |