Assay Detail
Binding
CHEMBL2388915
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Inhibition of recombinant human BACE1 extracellular domain expressed in baculovirus using Q-C(HS03)-lle-Asp-Leu-Ala-Val-Leu-Asp-HN-CH2-CH2-Mca as substrate incubated for 1 hr measured every 1 min for 15 mins by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dihydrooxazines As Inhibitors of BACE-1 or BACE-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.42 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386720 | — | — | 1 | 7.92 |
| CHEMBL2386719 | — | — | 1 | 7.92 |
| CHEMBL2386724 | — | — | 1 | 7.75 |
| CHEMBL2386726 | — | — | 1 | 7.72 |
| CHEMBL2386721 | — | — | 1 | 7.54 |
| CHEMBL2386723 | — | — | 1 | 7.46 |
| CHEMBL2386722 | — | — | 1 | 7.00 |
| CHEMBL2386725 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386720 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2386719 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2386724 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2386726 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2386721 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2386723 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2386722 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2386725 | — | IC50 | = | 830.0 | nM | 6.08 |