Assay Detail
Binding
CHEMBL2389097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type Candida albicans 1,3-beta-D-glucan synthase using UDP[6,3H]-glucose as substrate after 60 mins by liquid scintillation counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antifungal evaluation of pentyloxyl-diphenylisoxazoloyl pneumocandins and echinocandins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.76 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2387202 | — | — | 1 | 8.36 |
| CHEMBL2387203 | — | — | 1 | 7.75 |
| CHEMBL2387205 | — | — | 1 | 7.46 |
| CHEMBL3037784 | — | — | 1 | 7.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2387202 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL2387203 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL2387205 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3037784 | — | IC50 | = | 35.7 | nM | 7.45 |