Assay Detail

CHEMBL2389178

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Binding

Displacement of [3H]-nisoxetine from Sprague-Dawley rat brain NET after 1 hr

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.

Dreyfus N, Myers JK, Badescu VO, de Frutos O, de la Puente ML, Ding C, Filla SA, Fynboe K, Gernert DL, Heinz BA, Hemrick-Luecke SK, Johnson KW, Johnson MP, López P, Love PL, Martin LJ, Masquelin T, McCoy MJ, Mendiola J, Morrow D, Muhlhauser M, Pascual G, Perun TJ, Pfeifer LA, Phebus LA, Richards SJ, Rincón JA, Seest EP, Shah J, Shaojuan J, Simmons RM, Stephenson GA, Tromiczak EG, Thompson LK, Walter MW, Weber WW, Zarrinmayeh H, Thomas CE, Joshi E, Iyengar S, Johansson AM.
ACS Med Chem Lett (2013) 4 : 560 -564
PubMed 24900709 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	5	8.78	9.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2386162	—	—	1	9.64
CHEMBL1175	DULOXETINE	4.0	1	8.91
CHEMBL259209	MILNACIPRAN	4.0	1	7.80
CHEMBL1118	DESVENLAFAXINE	4.0	1	-
CHEMBL637	VENLAFAXINE	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2386162	—	Ki	=	0.23	nM	9.64
CHEMBL1175	DULOXETINE	Ki	=	1.24	nM	8.91
CHEMBL259209	MILNACIPRAN	Ki	=	16.0	nM	7.80
CHEMBL1118	DESVENLAFAXINE	Ki	>	316.0	nM	-
CHEMBL637	VENLAFAXINE	Ki	>	500.0	nM	-