Assay Detail
Binding
CHEMBL2389282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum FabZ using crotonoyl-CoA as substrate preincubated for 10 mins prior to substrate addition
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.07 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.16 |
| CHEMBL1484978 | EVERNIC ACID | — | 1 | 4.97 |
| CHEMBL463212 | VULPINIC ACID | — | 1 | 4.69 |
| CHEMBL176570 | PSOROMIC ACID | — | 1 | 4.45 |
| CHEMBL367881 | (+)-USNIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1484978 | EVERNIC ACID | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL463212 | VULPINIC ACID | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL176570 | PSOROMIC ACID | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL367881 | (+)-USNIC ACID | IC50 | > | 200000.0 | nM | - |