Assay Detail
Functional
CHEMBL2389286
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Antiplasmodial activity against blood stage of chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.39 | 4.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176570 | PSOROMIC ACID | — | 1 | 4.54 |
| CHEMBL367881 | (+)-USNIC ACID | — | 1 | 4.33 |
| CHEMBL463212 | VULPINIC ACID | — | 1 | 4.31 |
| CHEMBL1484978 | EVERNIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176570 | PSOROMIC ACID | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL367881 | (+)-USNIC ACID | IC50 | = | 47300.0 | nM | 4.33 |
| CHEMBL463212 | VULPINIC ACID | IC50 | = | 48500.0 | nM | 4.31 |
| CHEMBL1484978 | EVERNIC ACID | IC50 | = | 142100.0 | nM | - |