Assay Detail
Functional
CHEMBL2389359
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Cytotoxicity against human SW480 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.93 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386169 | — | — | 1 | 5.57 |
| CHEMBL2386344 | — | — | 1 | 5.30 |
| CHEMBL2386347 | — | — | 1 | 5.04 |
| CHEMBL2386348 | — | — | 1 | 4.96 |
| CHEMBL2386345 | — | — | 1 | 4.91 |
| CHEMBL2386350 | — | — | 1 | 4.84 |
| CHEMBL2386349 | — | — | 1 | 4.84 |
| CHEMBL2386346 | RO-5045337 | 1.0 | 1 | 4.78 |
| CHEMBL2386343 | — | — | 1 | 4.75 |
| CHEMBL2386170 | — | — | 1 | 4.64 |
| CHEMBL2386351 | — | — | 1 | 4.61 |
| CHEMBL2386167 | — | — | 1 | - |
| CHEMBL2386168 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386169 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2386344 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2386347 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL2386348 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2386345 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL2386350 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL2386349 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL2386346 | RO-5045337 | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL2386343 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL2386170 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL2386351 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL2386167 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2386168 | — | IC50 | > | 30000.0 | nM | - |