Assay Detail
Functional
CHEMBL2389360
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Cytotoxicity against human MDA-MB-435 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.89 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386169 | — | — | 1 | 5.38 |
| CHEMBL2386347 | — | — | 1 | 5.14 |
| CHEMBL2386349 | — | — | 1 | 5.02 |
| CHEMBL2386345 | — | — | 1 | 5.02 |
| CHEMBL2386346 | RO-5045337 | 1.0 | 1 | 5.00 |
| CHEMBL2386348 | — | — | 1 | 4.98 |
| CHEMBL2386343 | — | — | 1 | 4.83 |
| CHEMBL2386350 | — | — | 1 | 4.76 |
| CHEMBL2386170 | — | — | 1 | 4.60 |
| CHEMBL2386351 | — | — | 1 | 4.55 |
| CHEMBL2386344 | — | — | 1 | 4.53 |
| CHEMBL2386167 | — | — | 1 | - |
| CHEMBL2386168 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386169 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2386347 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2386349 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL2386345 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL2386346 | RO-5045337 | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL2386348 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL2386343 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL2386350 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL2386170 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL2386351 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL2386344 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL2386167 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2386168 | — | IC50 | > | 30000.0 | nM | - |