Assay Detail
Binding
CHEMBL2390224
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.30 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.42 |
| CHEMBL2387260 | — | — | 1 | 7.71 |
| CHEMBL2387230 | — | — | 1 | 7.67 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.66 |
| CHEMBL2387265 | — | — | 1 | 7.42 |
| CHEMBL2385102 | — | — | 1 | 6.26 |
| CHEMBL2387229 | — | — | 1 | 5.95 |
| CHEMBL2387253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL2387260 | — | Ki | = | 19.6 | nM | 7.71 |
| CHEMBL2387230 | — | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL85 | RISPERIDONE | Ki | = | 21.7 | nM | 7.66 |
| CHEMBL2387265 | — | Ki | = | 38.1 | nM | 7.42 |
| CHEMBL2385102 | — | Ki | = | 549.8 | nM | 6.26 |
| CHEMBL2387229 | — | Ki | = | 1125.3 | nM | 5.95 |
| CHEMBL2387253 | — | Ki | > | 10000.0 | nM | - |