Assay Detail
Binding
CHEMBL2390225
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Displacement of [3H]7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle after 60 mins by liquid scintillation counting analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Olfactory tubercle |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.62 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2387229 | — | — | 1 | 8.37 |
| CHEMBL2387253 | — | — | 1 | 8.32 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.01 |
| CHEMBL2387230 | — | — | 1 | 7.87 |
| CHEMBL2385102 | — | — | 1 | 7.51 |
| CHEMBL2387260 | — | — | 1 | 7.15 |
| CHEMBL2387265 | — | — | 1 | 7.14 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2387229 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL2387253 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL85 | RISPERIDONE | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL2387230 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL2385102 | — | Ki | = | 30.6 | nM | 7.51 |
| CHEMBL2387260 | — | Ki | = | 71.3 | nM | 7.15 |
| CHEMBL2387265 | — | Ki | = | 72.7 | nM | 7.14 |
| CHEMBL42 | CLOZAPINE | Ki | = | 239.8 | nM | 6.62 |