Assay Detail
Binding
CHEMBL2390337
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Inhibition of LPS-induced NF-kappaB activation in HEK293 cells incubated for 4 hrs prior to LPS challenge measured after 48 hrs by luciferase reporter gene assay
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anti-inflammatory secondary metabolites from the leaves of Rosa laevigata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 4 | - | - |
| IC50 | 4 | 4.30 | 4.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385208 | — | — | 2 | 4.63 |
| CHEMBL2385207 | — | — | 2 | 4.18 |
| CHEMBL515920 | — | — | 2 | 4.10 |
| CHEMBL239075 | EUSCAPHIC ACID | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385208 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL2385207 | — | IC50 | = | 65620.0 | nM | 4.18 |
| CHEMBL515920 | — | IC50 | = | 78960.0 | nM | 4.10 |
| CHEMBL2385208 | — | Inhibition | - | % | - | |
| CHEMBL239075 | EUSCAPHIC ACID | Inhibition | - | % | - | |
| CHEMBL515920 | — | Inhibition | - | % | - | |
| CHEMBL2385207 | — | Inhibition | - | % | - | |
| CHEMBL239075 | EUSCAPHIC ACID | IC50 | = | 174590.0 | nM | - |