Assay Detail
Binding
CHEMBL2390480
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Activation of recombinant AMPK alpha2beta1gamma1 (unknown origin) after 2 hrs by scintillation proximity assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.50 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1242297 | — | — | 1 | 6.52 |
| CHEMBL2386124 | — | — | 1 | 6.00 |
| CHEMBL2386114 | — | — | 1 | 5.92 |
| CHEMBL2386115 | — | — | 1 | 5.75 |
| CHEMBL2386118 | — | — | 1 | 5.50 |
| CHEMBL2385951 | — | — | 1 | 5.50 |
| CHEMBL2386116 | — | — | 1 | 5.40 |
| CHEMBL2386123 | — | — | 1 | 5.35 |
| CHEMBL2386120 | — | — | 1 | 5.34 |
| CHEMBL2385952 | — | — | 1 | 5.32 |
| CHEMBL2386113 | — | — | 1 | 5.23 |
| CHEMBL2386117 | — | — | 1 | 5.13 |
| CHEMBL2386122 | — | — | 1 | 5.04 |
| CHEMBL2386119 | — | — | 1 | 5.00 |
| CHEMBL2386121 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1242297 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2386124 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2386114 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2386115 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2386118 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2385951 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2386116 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2386123 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2386120 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2385952 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2386113 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2386117 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2386122 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2386119 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL2386121 | — | EC50 | > | 10000.0 | nM | - |