Assay Detail
Binding
CHEMBL2390489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type IDH1 (unknown origin) expressed in Escherichia coli BL21 using alpha-ketoglutarate as substrate incubated for 5 mins prior to substrate addition measured every 30 secs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Isocitrate dehydrogenase [NADP] cytoplasmic (CHEMBL2007625) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.85 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386126 | — | — | 1 | 4.91 |
| CHEMBL2386127 | — | — | 1 | 4.78 |
| CHEMBL2386130 | — | — | 1 | - |
| CHEMBL2386129 | — | — | 1 | - |
| CHEMBL2386128 | — | — | 1 | - |
| CHEMBL2386125 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386126 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL2386127 | — | Ki | = | 16800.0 | nM | 4.78 |
| CHEMBL2386130 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL2386129 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL2386128 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL2386125 | — | Ki | > | 50000.0 | nM | - |