Assay Detail
Functional
CHEMBL2390499
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Antitrypanosomal activity against Leishmania donovani MHOM-ET-67/L82 amastigotes after 72 hrs by Alamar blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.07 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 6.44 |
| CHEMBL1946738 | — | — | 1 | 5.27 |
| CHEMBL1946928 | — | — | 1 | 5.16 |
| CHEMBL1946929 | — | — | 1 | 4.94 |
| CHEMBL1946927 | — | — | 1 | 4.82 |
| CHEMBL1946741 | — | — | 1 | 4.76 |
| CHEMBL2386131 | — | — | 1 | 4.07 |
| CHEMBL2386133 | — | — | 1 | - |
| CHEMBL2386132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125 | MILTEFOSINE | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL1946738 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1946928 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1946929 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1946927 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1946741 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL2386131 | — | IC50 | = | 85100.0 | nM | 4.07 |
| CHEMBL2386133 | — | IC50 | = | 190400.0 | nM | - |
| CHEMBL2386132 | — | IC50 | = | 122700.0 | nM | - |