Assay Detail
Binding
CHEMBL2390517
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDR (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.57 | 8.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385579 | — | — | 1 | 8.78 |
| CHEMBL2385600 | — | — | 1 | 7.89 |
| CHEMBL2385586 | — | — | 1 | 7.85 |
| CHEMBL478629 | DORSOMORPHIN | — | 1 | 7.66 |
| CHEMBL513147 | — | — | 1 | 6.67 |
| CHEMBL2385596 | — | — | 1 | 5.82 |
| CHEMBL2385591 | — | — | 1 | 5.69 |
| CHEMBL511563 | — | — | 1 | 5.37 |
| CHEMBL2385582 | — | — | 1 | 5.27 |
| CHEMBL502351 | — | — | 1 | 4.71 |
| CHEMBL2385597 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385579 | — | IC50 | = | 1.68 | nM | 8.78 |
| CHEMBL2385600 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2385586 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL478629 | DORSOMORPHIN | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL513147 | — | IC50 | = | 214.7 | nM | 6.67 |
| CHEMBL2385596 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL2385591 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL511563 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2385582 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL502351 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL2385597 | — | IC50 | - | — | - |