Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2390594

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced ROS production after 1 hr by DCFH-DA staining-based fluorometric analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Cell Type PC-12
Confidence 1 — Organism
Curated By Autocuration

Target

PC-12 (CHEMBL612556)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists.
Azran S, Förster D, Danino O, Nadel Y, Reiser G, Fischer B.
J Med Chem (2013) 56 : 4938 -4952
PubMed 23751098 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.89 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3392138 1 7.10
CHEMBL2386495 1 6.75
CHEMBL2386496 1 6.72
CHEMBL2386492 1 6.70
CHEMBL2386498 1 6.40
CHEMBL2386493 1 6.00
CHEMBL2181938 1 6.00
CHEMBL2181939 1 6.00
CHEMBL2386499 1 5.92
CHEMBL2386494 1 5.58
CHEMBL2386497 1 5.30
CHEMBL153 TROLOX 1 4.70
CHEMBL14830 ADENOSINE DIPHOSPHATE 0.5 1 4.68
CHEMBL437508 1 4.54
CHEMBL14249 ADENOSINE TRIPHOSPHATE 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3392138 IC50 = 80.0 nM 7.10
CHEMBL2386495 IC50 = 180.0 nM 6.75
CHEMBL2386496 IC50 = 190.0 nM 6.72
CHEMBL2386492 IC50 = 200.0 nM 6.70
CHEMBL2386498 IC50 = 400.0 nM 6.40
CHEMBL2386493 IC50 = 1000.0 nM 6.00
CHEMBL2181938 IC50 = 1000.0 nM 6.00
CHEMBL2181939 IC50 = 1000.0 nM 6.00
CHEMBL2386499 IC50 = 1200.0 nM 5.92
CHEMBL2386494 IC50 = 2600.0 nM 5.58
CHEMBL2386497 IC50 = 5000.0 nM 5.30
CHEMBL153 TROLOX IC50 = 20000.0 nM 4.70
CHEMBL14830 ADENOSINE DIPHOSPHATE IC50 = 21000.0 nM 4.68
CHEMBL437508 IC50 = 29000.0 nM 4.54
CHEMBL14249 ADENOSINE TRIPHOSPHATE IC50 - -